STIMULATION OF THE PROTEINASEPROTEINASE INHIBITOR SYSTEM AS A RESULT OF IMMERSION HYPOTHERMIA [

The effect of immersion hypothermia (IН) on proteolysis activity in adult male rats, which was performed at 0 °C for 5 min the “forced swimming” test, studied; body temperature decreased to 27.5 ± 0.5°C. In blood serum and non-nuclear fractions homogenates cerebral cortex, hypothalamus, cerebellum, brainstem, lungs, heart, liver kidneys tissues were determined total proteinase (TPA), non-trypsin-like proteinases (NTPs), such as chymase, prostate-specific antigen, partially tonin, kallikrein rK9, well trypsin-inhibitory α-1-proteinase inhibitor (α-1-PI), α-2-macroglobulin (α-2-MG) by highly sensitive (10-9–10-10 g) enzymatic methods. It is noted that IH led TPA increase all studied (4-84 times), corresponds psycho-emotional effects phenomenon hormesis. After 24 h, decreased, remaining above control level, increased further (90 times). NTLP a result after h (7 heart. α-1-PI also heart kidneys, below brainstem remained high, protecting against proteolytic attack. α-2-MG maximum (2-5 - more significantly (24 but there no changes where its initial level biggest. Thus, development IG swimming cold water 0oC has stimulating leads significant activation reactions limited proteolysis.